Pub. Date : 2016 May
PMID : 26581908
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin inhibited activation of HER2 (Tyr1248)/HER3 (Tyr1289)/Akt (Ser473) as well as cell proliferation and colony formation by estrogenic promotion in MCF-7 and TR MCF-7 cells. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Consistent with the results in the two cell lines, we identified that metformin inhibited HER2/HER3/Akt signaling axis activated by HRG-beta1 using the HER2 and HER3-overexpressing breast cancer cell line SK-BR-3. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |