Title : Enhanced expression of c-myc in hepatocytes promotes initiation and progression of alcoholic liver disease.

Pub. Date : 2016 Mar

PMID : 26576483






2 Functional Relationships(s)
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1 Pathway analysis revealed that elevated c-myc expression and ethanol uptake synergistically lead to strong AKT activation, Mdm2 phosphorylation and as a consequence to inhibition of p53. Ethanol tumor protein p53 Homo sapiens
2 CONCLUSIONS: Expression of c-myc and EtOH-uptake synergistically accelerate the progression of ALD most likely due to loss of p53-dependent protection. Ethanol tumor protein p53 Homo sapiens