Pub. Date : 2015 Nov 10
PMID : 26553968
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 2 | We identified the low molecular weight compound 15,16-dihydrotanshinone-I (DHTS), well known in traditional Chinese medicine practice, through a validated high throughput screening on a set of anti-inflammatory agents for its ability to prevent HuR:RNA complex formation. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 3 | We identified the low molecular weight compound 15,16-dihydrotanshinone-I (DHTS), well known in traditional Chinese medicine practice, through a validated high throughput screening on a set of anti-inflammatory agents for its ability to prevent HuR:RNA complex formation. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 4 | We found that DHTS interferes with the association step between HuR and the RNA with an equilibrium dissociation constant in the nanomolar range in vitro (Ki = 3.74 +- 1.63 nM). | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 5 | In breast cancer cell lines, short term exposure to DHTS influences mRNA stability and translational efficiency of TNF in a HuR-dependent manner and also other functional readouts of its post-transcriptional control, such as the stability of selected pre-mRNAs. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 6 | Importantly, we show that migration and sensitivity of breast cancer cells to DHTS are modulated by HuR expression, indicating that HuR is among the preferential intracellular targets of DHTS. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 7 | Importantly, we show that migration and sensitivity of breast cancer cells to DHTS are modulated by HuR expression, indicating that HuR is among the preferential intracellular targets of DHTS. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 8 | Importantly, we show that migration and sensitivity of breast cancer cells to DHTS are modulated by HuR expression, indicating that HuR is among the preferential intracellular targets of DHTS. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 9 | Importantly, we show that migration and sensitivity of breast cancer cells to DHTS are modulated by HuR expression, indicating that HuR is among the preferential intracellular targets of DHTS. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |
| 10 | Here, we disclose a previously unrecognized molecular mechanism exerted by DHTS, opening new perspectives to therapeutically target the HuR mediated, post-transcriptional control in inflammation and cancer cells. | dhts | ELAV like RNA binding protein 1 | Homo sapiens |