Pub. Date : 2016 Jan 28
PMID : 26546044
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Alpha-fetoprotein is a biomarker of unfolded protein response and altered proteostasis in hepatocellular carcinoma cells exposed to sorafenib. | Sorafenib | alpha fetoprotein | Homo sapiens |
| 2 | A decrease in the serum levels of Alpha-fetoprotein (AFP) is reported to be the biological parameter that is best associated with disease control by sorafenib. | Sorafenib | alpha fetoprotein | Homo sapiens |
| 3 | A decrease in the serum levels of Alpha-fetoprotein (AFP) is reported to be the biological parameter that is best associated with disease control by sorafenib. | Sorafenib | alpha fetoprotein | Homo sapiens |
| 4 | In order to provide a biological rationale for the variations of AFP, we analyzed the various steps of AFP production in human HCC cell lines exposed to sorafenib. | Sorafenib | alpha fetoprotein | Homo sapiens |
| 5 | In order to provide a biological rationale for the variations of AFP, we analyzed the various steps of AFP production in human HCC cell lines exposed to sorafenib. | Sorafenib | alpha fetoprotein | Homo sapiens |
| 6 | Sorafenib dramatically reduced the levels of AFP produced by HCC cells independently of its effect on cell viability. | Sorafenib | alpha fetoprotein | Homo sapiens |
| 7 | The mRNA levels of AFP decreased upon sorafenib treatment, while the AFP protein remained localized in the Golgi apparatus. | Sorafenib | alpha fetoprotein | Homo sapiens |
| 8 | The inhibition of IRE-1alpha partially restored the mRNA levels of AFP upon treatment with sorafenib. | Sorafenib | alpha fetoprotein | Homo sapiens |
| 9 | The inhibition of both pathways partially prevented the drop in the production of AFP induced by sorafenib. | Sorafenib | alpha fetoprotein | Homo sapiens |