Pub. Date : 2016 May
PMID : 26541911
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | INTRODUCTION: In very novice smokers, CYP2A6 genotypes that reduce nicotine metabolism to an intermediate rate may increase smoking risk, relative to both normal and slow rates. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 2 | Predicted nicotine metabolic rate based on CYP2A6 diplotypes (CYP2A6 Diplotype Predicted Rate [CDPR]) was partitioned into Normal, Intermediate, and Slow categories using a metabolism metric. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 3 | Predicted nicotine metabolic rate based on CYP2A6 diplotypes (CYP2A6 Diplotype Predicted Rate [CDPR]) was partitioned into Normal, Intermediate, and Slow categories using a metabolism metric. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 4 | IMPLICATIONS: This study supports our recent hypothesis that CYP2A6 diplotypes that encode intermediate nicotine metabolism rate are associated with enhanced pleasurable events following the initial smoking attempt, compared with diplotypes that encode either normal or slow metabolism. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |