Title : Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production.

Pub. Date : 2016 Jan

PMID : 26535997






2 Functional Relationships(s)
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1 In wild-type mice, acute inflammation induced by single injections of heat-killed Brucella abortus or interleukin-1beta (IL-1beta) decreased serum iron within 6 h, and was accompanied by significant increases in osseous Fgf23 mRNA expression and serum levels of C-terminal FGF23, but no changes in intact FGF23. Iron interleukin 1 beta Mus musculus
2 Chronic inflammation induced by repeated bacteria or IL-1beta injections decreased serum iron, increased osseous Fgf23 mRNA, and serum C-terminal FGF23, but modestly increased biologically active, intact FGF23 serum levels. Iron interleukin 1 beta Mus musculus