Pub. Date : 2015
PMID : 26529495
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MK-1775 is the first-in-class selective Wee1 inhibitor which has been demonstrated to synergize with CHK1 inhibitors in various malignancies. | adavosertib | checkpoint kinase 1 | Homo sapiens |
| 2 | Interestingly, treatment with panobinostat alone or in combination with MK-1775 resulted in decreased Wee1 protein levels as well as downregulation of the CHK1 pathway. | adavosertib | checkpoint kinase 1 | Homo sapiens |
| 3 | shRNA knockdown of CHK1 significantly sensitized AML cells to MK-1775 treatment, while knockdown of Wee1 significantly enhanced both MK-1775- and panobinostat-induced cell death. | adavosertib | checkpoint kinase 1 | Homo sapiens |
| 4 | Our results demonstrate that panobinostat synergizes with MK-1775 in AML cells, at least in part through downregulation of CHK1 and/or Wee1, providing compelling evidence for the clinical development of the combination treatment in AML. | adavosertib | checkpoint kinase 1 | Homo sapiens |