Title : Effects of aspirin on expression of iron transport and storage proteins in BV-2 microglial cells.

Pub. Date : 2015 Dec

PMID : 26522688






3 Functional Relationships(s)
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1 We found that aspirin significantly down-regulated TfR1, while also up-regulated Fpn1 and ferritin expressions in BV-2 microglial cells in vitro. Aspirin transferrin receptor Mus musculus
2 We also showed that TfR1 and Fpn1 expressions were significantly higher, while ferritin contents, IL-6, TNF-alpha and hepcidin mRNA levels were lower in cells treated with aspirin plus LPS than those in cells treated with LPS only. Aspirin transferrin receptor Mus musculus
3 Our findings also suggested that hepcidin might play a dominant role in the control of TfR1 expression by aspirin in the cells treated with LPS. Aspirin transferrin receptor Mus musculus