Pub. Date : 2015 Nov 17
PMID : 26513172
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celecoxib increases lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. | Celecoxib | intercellular adhesion molecule 1 | Homo sapiens |
| 2 | Using lung cancer cell lines (A549, H460) and metastatic cells derived from a lung cancer patient, the present study investigates the impact of celecoxib on the expression of intercellular adhesion molecule 1 (ICAM-1) and cancer cell lysis by lymphokine-activated killer (LAK) cells. | Celecoxib | intercellular adhesion molecule 1 | Homo sapiens |
| 3 | Using lung cancer cell lines (A549, H460) and metastatic cells derived from a lung cancer patient, the present study investigates the impact of celecoxib on the expression of intercellular adhesion molecule 1 (ICAM-1) and cancer cell lysis by lymphokine-activated killer (LAK) cells. | Celecoxib | intercellular adhesion molecule 1 | Homo sapiens |
| 4 | Celecoxib, but not other structurally related selective COX-2 inhibitors (i.e., etoricoxib, rofecoxib, valdecoxib), was found to cause a substantial upregulation of ICAM-1 protein levels. | Celecoxib | intercellular adhesion molecule 1 | Homo sapiens |
| 5 | Likewise, ICAM-1 mRNA expression was increased by celecoxib. | Celecoxib | intercellular adhesion molecule 1 | Homo sapiens |
| 6 | Celecoxib enhanced the susceptibility of cancer cells to be lysed by LAK cells with the respective effect being reversed by a neutralizing ICAM-1 antibody. | Celecoxib | intercellular adhesion molecule 1 | Homo sapiens |
| 7 | In addition, enhanced killing of celecoxib-treated cancer cells was reversed by preincubation of LAK cells with an antibody to lymphocyte function associated antigen 1 (LFA-1), suggesting intercellular ICAM-1/LFA-1 crosslink as crucial event within this process. | Celecoxib | intercellular adhesion molecule 1 | Homo sapiens |
| 8 | Altogether, our data demonstrate celecoxib-induced upregulation of ICAM-1 on lung cancer cells to be responsible for intercellular ICAM-1/LFA-1 crosslink that confers increased cancer cell lysis by LAK cells. | Celecoxib | intercellular adhesion molecule 1 | Homo sapiens |
| 9 | Altogether, our data demonstrate celecoxib-induced upregulation of ICAM-1 on lung cancer cells to be responsible for intercellular ICAM-1/LFA-1 crosslink that confers increased cancer cell lysis by LAK cells. | Celecoxib | intercellular adhesion molecule 1 | Homo sapiens |