Title : Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target.

Pub. Date : 2016 Jan 1

PMID : 26510764






1 Functional Relationships(s)
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1 In this review, we propose that the functional and physical coupling of KCC2 to Cl(-)-sensitive kinase(s), such as the WNK1-SPAK kinase complex, constitutes a molecular "rheostat" that regulates [Cl(-)]i and thereby influences the functional plasticity of GABA. gamma-Aminobutyric Acid WNK lysine deficient protein kinase 1 Homo sapiens