Pub. Date : 2015 Dec
PMID : 26510321
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Targeting Mast Cells and Basophils with Anti-FcepsilonRIalpha Fab-Conjugated Celastrol-Loaded Micelles Suppresses Allergic Inflammation. | celastrol | FA complementation group B | Homo sapiens |
| 2 | Our present study aims at targeted delivery of anti-FcepsilonRIalpha Fab-conjugated celastrol-loaded micelles toward FcepsilonRIalpha receptors expressed on mast cells and basophils to have enhanced anti-allergic effect. | celastrol | FA complementation group B | Homo sapiens |
| 3 | The anti-FcepsilonRIalpha Fab-conjugated celastrol-loaded micelles revealed uniform particle size (93.43 +- 12.93 nm) with high loading percentage (21.2 +- 1.5% w/w). | celastrol | FA complementation group B | Homo sapiens |
| 4 | In addition, in mouse model of passive cutaneous anaphylaxis, anti-FcepsilonRIalpha Fab-conjugated celastrol-loaded micelles treatment significantly decreased extravasated evan"s in the ear. | celastrol | FA complementation group B | Homo sapiens |
| 5 | These results indicate that anti-FcepsilonRIalpha Fab-conjugated celastrol-loaded micelles can target and selectively kill mast cells and basophils which express FcepsilonRIalpha, and may be efficient reagents for the treatment of allergic disorders and mast cell related diseases. | celastrol | FA complementation group B | Homo sapiens |