Pub. Date : 1989
PMID : 2650928
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stimulation of plasma renin activity by captopril in renovascular hypertensive conscious dogs. | Captopril | renin | Canis lupus familiaris |
| 2 | This increase in plasma renin activity could result from either the concomitant fall in systemic pressure or other effects of captopril, such as the removal of an angiotensin II inhibitory effect on renin release, the increased production of bradykinin or prostaglandins, etc. | Captopril | renin | Canis lupus familiaris |
| 3 | Plasma renin activity, under normal conditions remained unchanged, while during hypertension it increased 2.0, 2.8 and 3.5 fold respectively in response to the three doses of captopril. | Captopril | renin | Canis lupus familiaris |
| 4 | These results suggest that the development of renovascular hypertension sensitized the kidney to release renin when challenged by captopril and that the effect is independent of changes in systemic pressure. | Captopril | renin | Canis lupus familiaris |