Title : Smac mimetic with TNF-α targets Pim-1 isoforms and reactive oxygen species production to abrogate transformation from blebbishields.

Pub. Date : 2016 Jan 1

PMID : 26508734






1 Functional Relationships(s)
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1 We also identified mitochondrial isoforms of Pim-1 kinase that were targeted for degradation by AZ58 in combination with TNF-alpha or AZ58 in combination with Fas ligand (FasL) plus cycloheximide (CHX) through caspase-3 to block transformation. Cycloheximide caspase 3 Homo sapiens