Title : Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1.

Pub. Date : 2015 Dec 1

PMID : 26508549






1 Functional Relationships(s)
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1 Finally, we have observed that alpha-mangostin selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells, presumably via restoring the activity of cellular alpha-KG-dependent DNA hydroxylases and histone H3 lysine demethylases. Lysine isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens