Title : Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier.

Pub. Date : 2016 Feb

PMID : 26507673






2 Functional Relationships(s)
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1 KEY RESULTS: Chemical or physical disruption of P-gp increased [(3) H]-verapamil transport by ~10-fold at the BBB and ~1.5-fold at the BRB. Verapamil phosphoglycolate phosphatase Mus musculus
2 [(3) H]-Verapamil transport involved influx-mediated by an organic cation clonidine-sensitive/diphenhydramine-sensitive proton antiporter at both barriers; this effect was unmasked when P-gp was partially or fully inhibited/disrupted at the BBB. Verapamil phosphoglycolate phosphatase Mus musculus