Pub. Date : 2015 Dec 25
PMID : 26505797
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Further studies showed that escin-induced Nrf2 activation in RPE cells required AKT signaling. | Escin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | AKT inhibitors (LY294002 and perifosine) blocked escin-induced AKT activation, and dramatically inhibited Nrf2 phosphorylation, its cytosol accumulation and nuclear translocation in RPE cells. | Escin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | AKT inhibitors (LY294002 and perifosine) blocked escin-induced AKT activation, and dramatically inhibited Nrf2 phosphorylation, its cytosol accumulation and nuclear translocation in RPE cells. | Escin | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Together, these results demonstrate that escin protects RPE cells from oxidative stress possibly through activating AKT-Nrf2 signaling. | Escin | AKT serine/threonine kinase 1 | Homo sapiens |