Title : The Frequency of Cytidine Editing of Viral DNA Is Differentially Influenced by Vpx and Nucleosides during HIV-1 or SIVMAC Infection of Dendritic Cells.

Pub. Date : 2015

PMID : 26496699






2 Functional Relationships(s)
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1 The restrictive phenotype of myeloid cells can be alleviated through the direct degradation of SAMHD1 by the HIV-2/SIVSM Vpx protein or else, at least in the case of HIV-1, by the exogenous supplementation of nucleosides that artificially overcome the catabolic activity of SAMHD1 on dNTPs. Nucleosides SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 Homo sapiens
2 The restrictive phenotype of myeloid cells can be alleviated through the direct degradation of SAMHD1 by the HIV-2/SIVSM Vpx protein or else, at least in the case of HIV-1, by the exogenous supplementation of nucleosides that artificially overcome the catabolic activity of SAMHD1 on dNTPs. Nucleosides SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 Homo sapiens