Pub. Date : 2016 Jan
PMID : 26496152
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | "Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes". | Glycolipids | CD1d1 antigen | Mus musculus |
| 2 | Invariant natural killer T (iNKT) cells recognize glycolipid antigens presented by CD1d, an antigen presenting protein structurally similar to MHC class I. Stimulation of iNKT cells by glycolipid antigens can induce strong immune responses in vivo, with rapid production of a wide variety of cytokines including those classically associated with either T helper type 1 (Th1) or type 2 (Th2) responses. | Glycolipids | CD1d1 antigen | Mus musculus |
| 3 | Alterations in the lipid tails or other portions of CD1d-presented glycolipid ligands can bias the iNKT response towards production of predominantly Th1 or Th2 associated cytokines. | Glycolipids | CD1d1 antigen | Mus musculus |
| 4 | Here we show that neutralization of endosomal pH enhanced localization of CD1d complexes containing Th2-biasing glycolipids to plasma membrane lipid rafts of antigen presenting cells (APC). | Glycolipids | CD1d1 antigen | Mus musculus |