Title : Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model.

Pub. Date : 2015 Dec

PMID : 26494859






1 Functional Relationships(s)
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1 Following combination treatment, gammaH2AX increased and Mdm2 localized to a larger degree to chromatin compared with single-agent treatment, consistent with previous observations that Mdm2 binds to the Mre11/Rad50/Nbs1 complex associated with DNA and inhibits the DNA damage response. gammah2ax transformed mouse 3T3 cell double minute 2 Mus musculus