Title : Early effects of the antineoplastic agent salinomycin on mitochondrial function.

Pub. Date : 2015 Oct 22

PMID : 26492365






2 Functional Relationships(s)
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1 Since at the concentration range used in most studies (around 10 muM) salinomycin exerts its effect at the level of mitochondria and alters bioenergetic performance, the specificity of its action on pathologic B cells isolated from patients with chronic lymphocytic leukemia (CLL) versus B cells from healthy subjects was investigated. salinomycin latexin Homo sapiens
2 The results indicate that salinomycin, when used above muM concentrations, exerts direct, mitochondrial effects, thus compromising cell survival. salinomycin latexin Homo sapiens