Title : Role of estrogen in lung cancer based on the estrogen receptor-epithelial mesenchymal transduction signaling pathways.

Pub. Date : 2015

PMID : 26491358






5 Functional Relationships(s)
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1 In the estrogen plus tamoxifen group, protein and mRNA expressions of ERalpha and AKT were dramatically reduced by tamoxifen treatment in tumor tissue compared with the estrogen group; mRNA expression of E-cadherin was increased in tumor tissue; protein expression of vimentin and PI3K were downregulated in tumor tissue; protein expression of E-cadherin increased in lung tissue; protein expression of ERalpha and PI3K were downregulated in lung tissue compared with the estrogen group. Tamoxifen thymoma viral proto-oncogene 1 Mus musculus
2 In the estrogen plus tamoxifen group, protein and mRNA expressions of ERalpha and AKT were dramatically reduced by tamoxifen treatment in tumor tissue compared with the estrogen group; mRNA expression of E-cadherin was increased in tumor tissue; protein expression of vimentin and PI3K were downregulated in tumor tissue; protein expression of E-cadherin increased in lung tissue; protein expression of ERalpha and PI3K were downregulated in lung tissue compared with the estrogen group. Tamoxifen thymoma viral proto-oncogene 1 Mus musculus
3 In the estrogen plus tamoxifen group, tamoxifen treatment dramatically reduced protein expression of ERalpha, ERbeta, AKT, and vimentin but significantly increased protein expression of E-cadherin in tumor tissues and lung tissue compared with the estrogen group. Tamoxifen thymoma viral proto-oncogene 1 Mus musculus
4 In the estrogen plus tamoxifen group, tamoxifen treatment dramatically reduced protein expression of ERalpha, ERbeta, AKT, and vimentin but significantly increased protein expression of E-cadherin in tumor tissues and lung tissue compared with the estrogen group. Tamoxifen thymoma viral proto-oncogene 1 Mus musculus
5 mRNA expression of ERbeta, PI3K, and AKT was dramatically reduced by tamoxifen treatment in lung tissues compared with the estrogen group. Tamoxifen thymoma viral proto-oncogene 1 Mus musculus