Title : The Cysteine-rich Domain of the DHHC3 Palmitoyltransferase Is Palmitoylated and Contains Tightly Bound Zinc.

Pub. Date : 2015 Dec 4

PMID : 26487721






3 Functional Relationships(s)
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1 The Cysteine-rich Domain of the DHHC3 Palmitoyltransferase Is Palmitoylated and Contains Tightly Bound Zinc. Cysteine zinc finger DHHC-type palmitoyltransferase 3 Homo sapiens
2 In this study, we present evidence using mass spectrometry that DHHC3 is palmitoylated at the cysteine in the DHHC motif. Cysteine zinc finger DHHC-type palmitoyltransferase 3 Homo sapiens
3 Treatment of DHHC3 with chelating agents in vitro replicated both the specific structural perturbations and activity deficits observed in conserved cysteine mutants, suggesting metal ion-binding in the CRD. Cysteine zinc finger DHHC-type palmitoyltransferase 3 Homo sapiens