Pub. Date : 2015 Dec
PMID : 26481537
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chelidonine, a principal isoquinoline alkaloid of Chelidonium majus, attenuates eosinophilic airway inflammation by suppressing IL-4 and eotaxin-2 expression in asthmatic mice. | chelidonine | chemokine (C-C motif) ligand 24 | Mus musculus |
| 2 | METHODS: The mice were sensitized to ovalbumin followed by aerosol allergen challenges and determination of chelidonine"s effect on enhanced pause (Penh), pulmonary eosinophilic infiltration, eotaxin-2, interleukin-4 (IL-4), IL-13, OVA-specific IgE production, and several transcription factors. | chelidonine | chemokine (C-C motif) ligand 24 | Mus musculus |
| 3 | RESULT: Chelidonine strongly suppressed airway eosinophilia, expression of eotaxin-2, IL-4, and IL-13 cytokine production in bronchoalveolar lavage fluid (BALF). | chelidonine | chemokine (C-C motif) ligand 24 | Mus musculus |
| 4 | CONCLUSIONS: Chelidonine has profound inhibitory effects on airway inflammation and this effect is caused by suppression of IL-4, eotaxin-2, and OVA-specific IgE production through the STAT6 and Foxp3 pathways. | chelidonine | chemokine (C-C motif) ligand 24 | Mus musculus |