Title : Modulation of 17β-Estradiol Signaling on Cellular Proliferation by Caveolin-2.

Pub. Date : 2016 Jun

PMID : 26480297






1 Functional Relationships(s)
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1 This study shows that siRNA-mediated caveolin-2 depletion in breast ductal carcinoma cells (MCF-7) reduces E2-induced ERalpha phosphorylation at serine residue 118 (S118), controls intracellular receptor levels, precludes ERalpha-mediated extra-nuclear activation of signaling pathways, reduces ERalpha transcriptional activity, and prevents cellular proliferation. Serine estrogen receptor 1 Homo sapiens