Pub. Date : 2015 Oct 15
PMID : 26469967
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | to show that genistein, a major component of isoflavone that is known to have anti-tumor activities in a variety of models, induces Bax/p53-independent cell death in HCT116 Bax knockout (KO), HCT116 p53 KO, DU145 Bax KO, or DU145 p53 KO cells that express wild-type (WT) Bak. | Genistein | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 2 | to show that genistein, a major component of isoflavone that is known to have anti-tumor activities in a variety of models, induces Bax/p53-independent cell death in HCT116 Bax knockout (KO), HCT116 p53 KO, DU145 Bax KO, or DU145 p53 KO cells that express wild-type (WT) Bak. | Genistein | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 3 | to show that genistein, a major component of isoflavone that is known to have anti-tumor activities in a variety of models, induces Bax/p53-independent cell death in HCT116 Bax knockout (KO), HCT116 p53 KO, DU145 Bax KO, or DU145 p53 KO cells that express wild-type (WT) Bak. | Genistein | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 4 | Our results also suggest that genistein may be an effective agent for overcoming chemoresistance in cancers with dysfunctional Bax and p53. | Genistein | BCL2 associated X, apoptosis regulator | Homo sapiens |