Pub. Date : 2016 Jun 16
PMID : 26455325
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Uptake of glutamine and subsequent glutaminolysis is critical for activation of the mTORC1 nutrient-sensing pathway, which regulates cell growth and protein translation in cancer cells. | Glutamine | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Pharmacological inhibitors of ASCT2-mediated transport significantly reduced glutamine uptake in human breast cancer cell lines, leading to the suppression of mTORC1 signalling, cell growth and cell cycle progression. | Glutamine | CREB regulated transcription coactivator 1 | Mus musculus |