Title : Activated PKR inhibits pancreatic β-cell proliferation through sumoylation-dependent stabilization of P53.

Pub. Date : 2015 Dec

PMID : 26446704






1 Functional Relationships(s)
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1 Additionally, a ceramide signal was needed for PKR activation to be triggered by glucolipotoxicity and TNFalpha stimulation, and stabilization of P53 required endogenous ceramide accumulation. Ceramides tumor necrosis factor Homo sapiens