Title : Crizotinib-induced antitumour activity in human alveolar rhabdomyosarcoma cells is not solely dependent on ALK and MET inhibition.

Pub. Date : 2015 Oct 6

PMID : 26445453






3 Functional Relationships(s)
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1 METHODS: RH4 and RH30 alveolar RMS (ARMS) cell lines were treated with crizotinib and then assessed by using proliferation, viability, migration and colony formation assays. Crizotinib Rh blood group D antigen Homo sapiens
2 The accumulation of reactive oxygen species (ROS) seemed to contribute to crizotinib effects in RH4 and RH30 cells. Crizotinib Rh blood group D antigen Homo sapiens
3 Moreover, crizotinib-treated RH4 and RH30 cells exhibited a decreased migratory/invasive capacity and clonogenic potential. Crizotinib Rh blood group D antigen Homo sapiens