Title : Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling.

Pub. Date : 2015 Dec

PMID : 26431905






3 Functional Relationships(s)
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1 We evaluated the effects of the ROS inhibitor N-acetylcysteine (NAC) and the JNK inhibitor SP600125 on fluoride-induced SIRT1/autophagy activation. pyrazolanthrone sirtuin 1 Mus musculus
2 SP600125 attenuated fluoride-induced SIRT1 phosphorylation, indicating that fluoride activates SIRT1/autophagy via the ROS-mediated JNK pathway. pyrazolanthrone sirtuin 1 Mus musculus
3 SP600125 attenuated fluoride-induced SIRT1 phosphorylation, indicating that fluoride activates SIRT1/autophagy via the ROS-mediated JNK pathway. pyrazolanthrone sirtuin 1 Mus musculus