Pub. Date : 2015 Nov
PMID : 26429918
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CONTEXT: The effect of pegvisomant on IGF1 levels in patients with acromegaly is well documented, but little is known of its long-term impact on comorbidity. | pegvisomant | insulin like growth factor 1 | Homo sapiens |
| 2 | RESULTS: At the first cardiac evaluation, 20+-16 months after pegvisomant introduction, IGF1 levels normalized in 29 (69%) of the 42 patients. | pegvisomant | insulin like growth factor 1 | Homo sapiens |
| 3 | CONCLUSIONS: Long-term pegvisomant therapy not only normalizes IGF1 in a large proportion of patients but also improves cardiac and respiratory comorbidity. | pegvisomant | insulin like growth factor 1 | Homo sapiens |