Title : Halogenated quinolines discovered through reductive amination with potent eradication activities against MRSA, MRSE and VRE biofilms.

Pub. Date : 2015 Nov 7

PMID : 26414088






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1 Halogenated quinolines discovered through reductive amination with potent eradication activities against MRSA, MRSE and VRE biofilms. Quinolines solute carrier family 9 member A6 Homo sapiens
2 Here, we report the discovery of several halogenated quinolines (HQs) identified through a reductive amination reaction that demonstrated potent eradication of MRSA (HQ-6; MBEC = 125 muM), MRSE (HQ-3; MBEC = 3.0 muM) and VRE (HQ-4, HQ-5 and HQ-6; MBEC = 1.0 muM) biofilms. Quinolines solute carrier family 9 member A6 Homo sapiens