Pub. Date : 2015 Dec
PMID : 26410305
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DAB2IP regulates the chemoresistance to pirarubicin and tumor recurrence of non-muscle invasive bladder cancer through STAT3/Twist1/P-glycoprotein signaling. | pirarubicin | DAB2 interacting protein | Homo sapiens |
| 2 | Mechanistically, DAB2IP could inhibit the phosphorylation and transactivation of STAT3, and then subsequently suppress the expression of Twist1 and its target gene P-glycoprotein, both of which were crucial for the pirarubicin chemoresistance and tumor re-growth of bladder cancer cells. | pirarubicin | DAB2 interacting protein | Homo sapiens |