Title : Salinomycin possesses anti-tumor activity and inhibits breast cancer stem-like cells via an apoptosis-independent pathway.

Pub. Date : 2015 Oct 30

PMID : 26407842






2 Functional Relationships(s)
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1 Mammosphere formation assays revealed that salinomycin suppresses self-renewal of ALDH1-positive BCSCs and downregulates the transcription factors Nanog, Oct4 and Sox2. salinomycin aldehyde dehydrogenase 1 family member A1 Homo sapiens
2 TUNEL analysis of MDA-MB-231-derived xenografts revealed that salinomycin administration elicited a significant reduction in tumor growth with a marked downregulation of ALDH1 and CD44 levels, but seemingly without the induction of apoptosis. salinomycin aldehyde dehydrogenase 1 family member A1 Homo sapiens