Pub. Date : 2015 Nov
PMID : 26388264
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The PDE models are based on experimental studies performed on purified PDEs which have demonstrated that cAMP and cGMP bind competitively to the cyclic nucleotide (cN)-binding domains of PDEs 1, 2, and 3, while PDE4 regulation occurs via PKA-mediated phosphorylation. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 2 | Individual PDE models reproduce experimentally measured cAMP hydrolysis rates with dose-dependent cGMP regulation. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 3 | These results provide insights into how PDEs transduce cGMP signals to regulate cAMP and how PDE interactions affect cardiac beta-adrenergic response. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |