Title : Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells.

Pub. Date : 2015

PMID : 26368816






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The IDH1 inhibitor AGI-5198 abrogates the ability of mutant IDH1 to produce the oncometabolite D-2 hydroxyglutarate (D-2HG) in gliomas. AGI-5198 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 The IDH1 inhibitor AGI-5198 abrogates the ability of mutant IDH1 to produce the oncometabolite D-2 hydroxyglutarate (D-2HG) in gliomas. AGI-5198 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens