Title : Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation.

Pub. Date : 2015 Sep 14

PMID : 26365875






2 Functional Relationships(s)
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1 Here we report that the biological activity of IL-33 at its receptor ST2 is rapidly terminated in the extracellular environment by the formation of two disulphide bridges, resulting in an extensive conformational change that disrupts the ST2 binding site. disulphide ST2 Homo sapiens
2 Here we report that the biological activity of IL-33 at its receptor ST2 is rapidly terminated in the extracellular environment by the formation of two disulphide bridges, resulting in an extensive conformational change that disrupts the ST2 binding site. disulphide ST2 Homo sapiens