Title : Design, synthesis, and biological evaluation of amide imidazole derivatives as novel metabolic enzyme CYP26A1 inhibitors.

Pub. Date : 2015 Oct 15

PMID : 26365710






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 CYP26A1 enzyme, induced by ATRA in liver and target tissues, metabolizes ATRA into 4-hydroxyl-RA. Tretinoin cytochrome P450 family 26 subfamily A member 1 Homo sapiens
2 CYP26A1 enzyme, induced by ATRA in liver and target tissues, metabolizes ATRA into 4-hydroxyl-RA. Tretinoin cytochrome P450 family 26 subfamily A member 1 Homo sapiens
3 Herein, we describe the design, synthesis and biological evaluation of a series of new amide imidazole derivatives as retinoic acid metabolism blocking agents (RAMBAs) toward CYP26A1 enzyme. Tretinoin cytochrome P450 family 26 subfamily A member 1 Homo sapiens