Title : The HSP90 inhibitor, 17AAG, protects the intestinal stem cell niche and inhibits graft versus host disease development.

Pub. Date : 2016 Jun 2

PMID : 26364610






1 Functional Relationships(s)
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1 Since the HSP90 inhibitor 17-allylamino-demethoxygeldanamycin (17AAG) is developed in clinics, we explored here its ability to control intestinal acute GvHD in vivo in two mouse GvHD models (C57BL/6 BALB/c and FVB/N Lgr5-eGFP), ex vivo in intestine organoids and in vitro in intestinal epithelial cultures. 17-allylamino-demethoxygeldanamycin heat shock protein 86, pseudogene 1 Mus musculus