Title : Low-Concentration Arsenic Trioxide Inhibits Skeletal Myoblast Cell Proliferation via a Reactive Oxygen Species-Independent Pathway.

Pub. Date : 2015

PMID : 26359868






3 Functional Relationships(s)
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1 As2O3 decreased myoblast growth at submicromolar concentrations (0.25-1 muM) after 72 h of treatment. Arsenic Trioxide latexin Homo sapiens
2 Low-concentration As2O3 (0.5 and 1 muM) significantly suppressed the myoblast cell proliferative activity, which was accompanied by a small proportion of bromodeoxyuridine (BrdU) incorporation and decreased proliferating cell nuclear antigen (PCNA) protein expression. Arsenic Trioxide latexin Homo sapiens
3 As2O3 (0.5 and 1 muM) increased the intracellular arsenic content but did not affect the reactive oxygen species (ROS) levels in the myoblasts. Arsenic Trioxide latexin Homo sapiens