Title : Orphan nuclear receptor oestrogen-related receptor γ (ERRγ) plays a key role in hepatic cannabinoid receptor type 1-mediated induction of CYP7A1 gene expression.

Pub. Date : 2015 Sep 1

PMID : 26348907






2 Functional Relationships(s)
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1 Overexpression of ERRgamma led to increased bile acid levels, whereas an inverse agonist of ERRgamma, GSK5182, reduced CYP7A1 expression and bile acid synthesis. GSK5182 cytochrome P450, family 7, subfamily a, polypeptide 1 Mus musculus
2 Finally, GSK5182 significantly reduced hepatic CB1 receptor-mediated induction of CYP7A1 expression and bile acid synthesis in alcohol-treated mice. GSK5182 cytochrome P450, family 7, subfamily a, polypeptide 1 Mus musculus