Title : Effects of CYP2B6 and CYP1A2 Genetic Variation on Nevirapine Plasma Concentration and Pharmacodynamics as Measured by CD4 Cell Count in Zimbabwean HIV-Infected Patients.

Pub. Date : 2015 Sep

PMID : 26348712






5 Functional Relationships(s)
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1 Effects of CYP2B6 and CYP1A2 Genetic Variation on Nevirapine Plasma Concentration and Pharmacodynamics as Measured by CD4 Cell Count in Zimbabwean HIV-Infected Patients. Nevirapine cytochrome P450 family 2 subfamily B member 6 Homo sapiens
2 This study, therefore, aimed to identify sources of variability in nevirapine pharmacokinetics and pharmacodynamics, focusing on genetic variation in CYP2B6 and CYP1A2. Nevirapine cytochrome P450 family 2 subfamily B member 6 Homo sapiens
3 CYP2B6 and CYP1A2 were chosen as the candidate genes based on reports in literature, as well as their prominence in the metabolism of efavirenz, a drug in the same class with nevirapine. Nevirapine cytochrome P450 family 2 subfamily B member 6 Homo sapiens
4 We conclude that CYP2B6 c.516G>T and CYP2B6 c.983T>C could be important sources of nevirapine pharmacokinetic variability that could be considered for dosage optimization, while CYP1A2 g.-163C>A seems to be associated with HIV disease progression. Nevirapine cytochrome P450 family 2 subfamily B member 6 Homo sapiens
5 We conclude that CYP2B6 c.516G>T and CYP2B6 c.983T>C could be important sources of nevirapine pharmacokinetic variability that could be considered for dosage optimization, while CYP1A2 g.-163C>A seems to be associated with HIV disease progression. Nevirapine cytochrome P450 family 2 subfamily B member 6 Homo sapiens