Title : Enantioselective NHC-Catalyzed Redox [4 + 2]-Hetero-Diels-Alder Reactions Using α,β-Unsaturated Trichloromethyl Ketones as Amide Equivalents.

Pub. Date : 2015 Oct 2

PMID : 26344498






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The initially formed syn-dihydropyranone products can be isolated or can undergo ring-opening with benzylamine followed by aminolysis of the resulting CCl3 ketone to form a range of diamides with high diastereo- and enantioselectivity (up to >95:5 dr and >99% ee). Diamide synemin Homo sapiens