Pub. Date : 2015 Sep 22
PMID : 26342198
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, blockage of the beta1-integrin/FAK/PI3K/AKT/mTOR pathway by siRNA or specific chemical inhibitors, or rescue of p53 activation can partially reverse the switch of glucose metabolism and inhibit the migration of Twist-overexpressing MCF10A cells and Twist-positive breast cancer cells. | Glucose | tumor protein p53 | Homo sapiens |
| 2 | Thus, our data suggest that Twist promotes reprogramming of glucose metabolism in MCF10A-Twist cells and Twist-positive breast cancer cells via activation of the beta1-integrin/FAK/PI3K/AKT/mTOR pathway and inhibition of the p53 pathway. | Glucose | tumor protein p53 | Homo sapiens |