Title : Metabolic activation of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and DNA adduct formation depends on p53: Studies in Trp53(+/+),Trp53(+/-) and Trp53(-/-) mice.

Pub. Date : 2016 Feb 15

PMID : 26335255






2 Functional Relationships(s)
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1 The expression of the tumor suppressor p53 can influence the bioactivation of, and DNA damage induced by, the environmental carcinogen benzo[a]pyrene, indicating a role for p53 in its cytochrome P450 (CYP)-mediated biotransformation. Benzo(a)pyrene cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus
2 The expression of the tumor suppressor p53 can influence the bioactivation of, and DNA damage induced by, the environmental carcinogen benzo[a]pyrene, indicating a role for p53 in its cytochrome P450 (CYP)-mediated biotransformation. Benzo(a)pyrene cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus