Pub. Date : 2015 Nov 2
PMID : 26335060
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In response to in vitro stimulation with lipopolysaccharide (LPS), microglia induce the production of the inflammatory cytokine interleukin-1 beta (IL-1beta) together with nitric oxide (NO) and superoxide anion (O2(-)). | Superoxides | interleukin 1 beta | Homo sapiens |
| 2 | Here we investigated the role of NO and O2(-) in the signaling mechanism by which IL-1beta is induced in microglia. | Superoxides | interleukin 1 beta | Homo sapiens |
| 3 | The LPS-inducible IL-1beta was significantly suppressed by pretreatment with the NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide, but not by pretreatment with the O2(-) scavenger N-acetyl cysteine, suggesting the close association of NO with IL-1beta induction. | Superoxides | interleukin 1 beta | Homo sapiens |