Title : Binding position of phenylbutazone with bovine serum albumin determined by measuring nuclear magnetic resonance relaxation time.

Pub. Date : 1989 Dec

PMID : 2632068






6 Functional Relationships(s)
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1 Binding position of phenylbutazone with bovine serum albumin determined by measuring nuclear magnetic resonance relaxation time. Phenylbutazone albumin Homo sapiens
2 The binding of phenylbutazone (PB) to bovine serum albumin (BSA) was considered to be predominantly due to hydrophobic interaction based on the thermodynamic parameters obtained by an equilibrium dialysis method. Phenylbutazone albumin Homo sapiens
3 The binding of phenylbutazone (PB) to bovine serum albumin (BSA) was considered to be predominantly due to hydrophobic interaction based on the thermodynamic parameters obtained by an equilibrium dialysis method. Phenylbutazone albumin Homo sapiens
4 The spin-lattice relaxation time (T1) of PB was almost concentration-independent, but decreased in the presence of BSA to 36-38% for the phenyl group and 48-100% for the butyl group. Phenylbutazone albumin Homo sapiens
5 The spin-spin relaxation time (T2) of PB was also almost independent of concentration, but was remarkably decreased in the presence of BSA to ca. Phenylbutazone albumin Homo sapiens
6 The binding of PB to BSA was considered to involve primarily the phenyl group. Phenylbutazone albumin Homo sapiens