Title : Design, synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as potential PDE4 inhibitors.

Pub. Date : 2015 Oct 15

PMID : 26320621






1 Functional Relationships(s)
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Protein Name
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1 The docking results showed that the catechol diether moiety of compound 8 played a key role to form integral hydrogen bonds with PDE4B protein while the rest part of the molecule extended into the catalytic domain to block the access of cAMP and formed the foundation for inhibition of PDE4. catechol phosphodiesterase 4B Homo sapiens