Title : In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin.

Pub. Date : 2016 Jan

PMID : 26319048






1 Functional Relationships(s)
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1 We have previously shown that the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor simvastatin directly inhibits ABCB1, alters the glycosylation of the transporter, and enhances the intracellular accumulation of doxorubicin with subsequent anti-cancer action. Simvastatin 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens