Title : Exogenous administration of DLK1 ameliorates hepatic steatosis and regulates gluconeogenesis via activation of AMPK.

Pub. Date : 2016 Feb

PMID : 26315841






3 Functional Relationships(s)
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1 Furthermore, DLK1-treated mice showed significantly lower levels of fasting and random glucose, with improved glucose and insulin tolerance compared with the vehicle-treated group. Glucose delta like non-canonical Notch ligand 1 Mus musculus
2 Moreover, DLK1 suppressed glucose production from hepatocytes, which was blocked after co-administration of an AMPK inhibitor, compound C. DLK1-treated hepatocytes and mouse liver tissues showed lower PEPCK and G6Pase expression. Glucose delta like non-canonical Notch ligand 1 Mus musculus
3 Moreover, DLK1 suppressed glucose production from hepatocytes, which was blocked after co-administration of an AMPK inhibitor, compound C. DLK1-treated hepatocytes and mouse liver tissues showed lower PEPCK and G6Pase expression. Glucose delta like non-canonical Notch ligand 1 Mus musculus