Title : α-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway.

Pub. Date : 2015 Aug 27

PMID : 26313911






3 Functional Relationships(s)
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1 alpha-Solanine-induced autophagic flux was demonstrated by additionally enhanced--turnover of LC3-II and--accumulation of LC3-specific puncta after co-incubation of cells with either of the autophagolysosome inhibitors--chloroquine and--bafilomycin A1. alpha-solanine microtubule associated protein 1 light chain 3 alpha Homo sapiens
2 alpha-Solanine-induced autophagic flux was demonstrated by additionally enhanced--turnover of LC3-II and--accumulation of LC3-specific puncta after co-incubation of cells with either of the autophagolysosome inhibitors--chloroquine and--bafilomycin A1. alpha-solanine microtubule associated protein 1 light chain 3 alpha Homo sapiens
3 We also demonstrated alpha-solanine-induced oxidative damage in regulating autophagy where pre-incubation of cells with reactive oxygen species (ROS) scavenger resulted in suppression of CM-H2DCFDA (5 (and 6)-chloromethyl-2",7"-dichlorodihydrofluorescein diacetate acetyl ester) fluorescence as well as decrease in LC3-II turnover. alpha-solanine microtubule associated protein 1 light chain 3 alpha Homo sapiens